Mammary analogue secretory carcinoma of the salivary glands: a diagnostic dilemma. Issue 3 (April 2017)

• Record Type: Journal Article
• Authors: Hindocha, N.; Wilson, M.H.; Pring, M.; Hughes, C.W.; Thomas, S.J.
• Is Part Of: British journal of oral and maxillofacial surgery. Volume 55:Issue 3(2017)
• Page Start: 290
• Page End: 292
• Publication Date: 2017-04
• Subjects: Mammary analogue secretory carcinoma -- MASC -- salivary gland malignancy -- minor salivary gland -- lip -- ETV6-NTRK3 translocation; Mouth -- Surgery -- Periodicals; Maxilla -- Surgery -- Periodicals; Face -- Surgery -- Periodicals; Surgery, Plastic -- Periodicals; Dentistry, Operative -- Periodicals; Face -- surgery -- Periodicals; Mouth -- surgery -- Periodicals; Maxilla -- surgery -- Periodicals; Surgery, Oral -- Periodicals; Oral Surgical Procedures -- Periodicals; Dentistry, Operative -- Periodicals; Bouche -- Chirurgie -- Périodiques; Maxillaire supérieur -- Chirurgie -- Périodiques; Face -- Chirurgie -- Périodiques; Chirurgie dentaire -- Périodiques; Dentistry, Operative; Face -- Surgery; Maxilla -- Surgery; Mouth -- Surgery; Surgery, Plastic; Electronic journals; Periodicals; 617.52059
• DOI: 10.1016/j.bjoms.2016.07.029
• Languages: English
• ISSNs: 0266-4356

Abstract

Abstract: Mammary analogue secretory carcinoma (MASC) is a recently identified salivary gland neoplasm that can mimic other salivary gland tumours such as acinic cell carcinoma and cystadenocarcinoma. It is distinguished from these by differences in immunohistochemical profile and the identification of an ETV6-NTRK3 translocation (12;15)(p13;q25), which is also found in secretory carcinomas of the breast. Previous publications have suggested that MASC tumours have similar biological behaviour to acinic cell carcinoma. We report two cases of MASC that affected the upper lip, and showed an infiltrative and locally aggressive growth pattern that required several operations to ensure clearance of microscopic tumour cells.