Isolation and synthesis of pygmanilines, phenylurea derivatives from the Northeastern Atlantic lichen Lichina pygmaea. Issue 12 (22nd March 2017)

• Record Type: Journal Article
• Authors: Mahajan, Nipun; Chadda, Rekha; Calabro, Kevin; Solanki, Hiren; O' Connell, Enda; Murphy, Paul V.; Thomas, Olivier P.
• Is Part Of: Tetrahedron letters. Volume 58:Issue 12(2017)
• Page Start: 1237
• Page End: 1239
• Publication Date: 2017-03-22
• Subjects: Lichina pygmaea -- Antioxidants -- Phenylurea -- Lichen; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2017.02.037
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Marine bioprospecting as a source of bioactives. Antioxidant natural products in marine organisms. Lichens as a source of bioactive natural product. Nitrogenated resorcinol derivatives. Abstract: A library of 864 extracts prepared from Irish marine organisms was screened in the search for novel antioxidants. Chemical investigation of the most promising extract obtained from the common lichen Lichina pygmaea led to the isolation of five resorcinol derivatives. An unusual urea moiety was found embedded in two of these compounds, pygmanilines A (1 ) and B (2 ) and their structures were confirmed by one-step chemical syntheses.