Sphaerialactonam, a γ-lactam–isochromanone from the Hawaiian endophytic fungus Paraphaeosphaeria sp. FT462. Issue 13 (29th March 2017)

• Record Type: Journal Article
• Authors: Huang, Peng; Li, Chunshun; Sarotti, Ariel M.; Turkson, James; Cao, Shugeng
• Is Part Of: Tetrahedron letters. Volume 58:Issue 13(2017)
• Page Start: 1330
• Page End: 1333
• Publication Date: 2017-03-29
• Subjects: Hawaii -- Endophytic -- NMR -- Lactam-isochromanone -- Anti-proliferative -- NMR calculations; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2017.02.052
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Sphaerialactonam with a unique structure has not been reported before. NMR calculation was utilized to determine the stereochemistry of sphaerialactonam. The biosynthesis of sphaerialactonam has been proposed. Abstract: Reinvestigation of the endophytic fungus Paraphaeosphaeria sp. FT462 from the Hawaiian plant Lycopodiella cernua (L.) Pic. Serm led to the isolation and identification of a unique γ-lactam-isochromanone (1 ). The structure of1 was determined by NMR, MS spectroscopic analysis, and quantum chemical calculations of NMR. The compound was tested inactive against A2780 and A2780cisR.