Cell fate regulation by chromatin ADP-ribosylation. (March 2017)

• Record Type: Journal Article
• Authors: Abplanalp, Jeannette; Hottiger, Michael O.
• Is Part Of: Seminars in cell & developmental biology. Volume 63(2017)
• Page Start: 114
• Page End: 122
• Publication Date: 2017-03
• Subjects: ARTD -- PARP -- Chromatin -- Histone -- ADP-ribosylation -- Differentiation -- Pluripotency; Cytology -- Periodicals; Developmental biology -- Periodicals; 571.6
• DOI: 10.1016/j.semcdb.2016.09.010
• Languages: English
• ISSNs: 1084-9521

Abstract

Abstract: ADP-ribosylation is an evolutionarily conserved complex posttranslational modification that alters protein function and/or interaction. Intracellularly, it is mainly catalyzed by diphtheria toxin-like ADP-ribosyltransferases (ARTDs), which attach one or several ADP-ribose residues onto target proteins. Several specific mono- and poly-ADP-ribosylation binding modules exist; hydrolases reverse the modification. The best-characterized ARTD family member, ARTD1, regulates various DNA-associated processes. Here, we focus on the role of ARTD1-mediated chromatin ADP-ribosylation in development, differentiation, and pluripotency, and the recent development of new methodologies that will enable more insight into these processes.