Metabolic roles of poly(ADP-ribose) polymerases. (March 2017)

• Record Type: Journal Article
• Authors: Vida, András; Márton, Judit; Mikó, Edit; Bai, Péter
• Is Part Of: Seminars in cell & developmental biology. Volume 63(2017)
• Page Start: 135
• Page End: 143
• Publication Date: 2017-03
• Subjects: ABCA1 ATP-binding cassette sub-family A member 1 -- ACACA acetyl-CoA carboxylase alpha -- ACBD3 acyl-CoA binding domain containing 3 -- ACLY ATP citrate lyase -- ADP adenosine diphosphate -- ADPR ADP-ribose -- AFLD alcoholic fatty liver disease -- AIF apoptosis inducing factor -- AMPK AMP activated kinase -- ANT adenine nucleotide translocase -- ARH3 ADP-ribosylhydrolase 3 -- CLOCK circadian locomotor output cycles kaput -- CRY cryptochrome circadian clock -- DNA deoxyribonucleic acid -- EPHX1 microsomal epoxide hydrolase -- ER estrogen receptor -- ERK extracellular signal-regulated kinase -- FA fatty acid -- FASN fatty acid synthase -- FDPS farnesyl diphosphate synthase -- FOXO1 forkhead box protein O1 -- GLP-1 glucagon-like peptide-1 -- GSK3 glycogen synthase kinase-3 -- HIF hypoxia-inducible factor -- HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase -- HMGCS 3-hydroxy-3-methylglutaryl-coenzyme A synthase -- LDLR low density lipoprotein receptor -- LXR liver X receptor -- ME2 malic enzyme 2 -- miRNA micro-ribonucleic acid -- mTOR mechanistic target of rapamycin -- MTP mitochondrial transition pore -- NAD nicotinamide adenine dinucleotide -- NAFLD non-alcoholic fatty liver disease -- NOR-1 neuron-derived orphan receptor 1 -- NR4A nuclear receptor subfamily 4 group A -- NRF nuclear respiratory factor -- NUDIX nucleoside diphosphate linked to X -- PAR poly(ADP-ribose) -- PARG poly(ADP-ribose) glycohydrolase -- PARP poly(ADP-ribose) polymerase -- PARPi poly(ADP-ribose) polymerase inhibitor -- PARylation poly(ADP-ribosyl)ation -- PDX-1 pancreatic and duodenal homeobox 1 -- PER period circadian clock -- PGC-1α peroxisome proliferator-activated receptor gamma coactivator 1-alpha -- PI3K Phosphatidylinositol 3-kinase -- PPAR peroxisome proliferators activated receptor -- PR progesterone receptor -- RAR retinoic acid receptor -- RNA ribonucleic acid -- RXR retinoic X receptor -- SCD stearoyl-CoA desaturase (delta-9-desaturase) -- SIRT sirtuin -- SREBP sterol-regulated element binding proteins -- TG triglyceride -- TNK1 Tyrosine Kinase Non Receptor 1 -- TR thyroid hormone receptor -- WAT white adipose tissue; PARP -- ARTD -- Metabolism -- Mitochondria -- Diabetes -- Obesity; Cytology -- Periodicals; Developmental biology -- Periodicals; 571.6
• DOI: 10.1016/j.semcdb.2016.12.009
• Languages: English
• ISSNs: 1084-9521

Abstract

Highlights: PARP enzymes regulate metabolic transcription factors and energy sensor systems. PARP-1 and PARP-2 regulate mitochondrial oxidation. PARPs are involved in higher order metabolic regulation and in the pathogenesis of metabolic diseases. Abstract: Poly(ADP-ribosyl)ation (PARylation) is an evolutionarily conserved reaction that had been associated with numerous cellular processes such as DNA repair, protein turnover, inflammatory regulation, aging or metabolic regulation. The metabolic regulatory tasks of poly(ADP-ribose) polymerases (PARPs) are complex, it is based on the regulation of metabolic transcription factors (e.g. SIRT1, nuclear receptors, SREBPs) and certain cellular energy sensors. PARP over-activation can cause damage to mitochondrial terminal oxidation, while the inhibition of PARP-1 or PARP-2 can induce mitochondrial oxidation by enhancing the mitotropic tone of gene transcription and signal transduction. These PARP-mediated processes impact on higher order metabolic regulation that modulates lipid metabolism, circadian oscillations and insulin secretion and signaling. PARP-1, PARP-2 and PARP-7 are related to metabolic diseases such as diabetes, alcoholic and non-alcoholic fatty liver disease (AFLD, NAFLD), or on a broader perspective to Warburg metabolism in cancer or the metabolic diseases accompanying aging.