Deheiculatins A-L, 20-oxygenated cembranoids from Macaranga deheiculata. (April 2017)

• Record Type: Journal Article
• Authors: Qi, Wei-Yan; Shen, Yu; Wu, Yan; Leng, Ying; Gao, Kun; Yue, Jian-Min
• Is Part Of: Phytochemistry. Volume 136(2017)
• Page Start: 101
• Page End: 107
• Publication Date: 2017-04
• Subjects: Macaranga deheiculata -- Cembrane diterpenoids -- Dehiculatins -- 11β-HSD1; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2017.01.009
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: Twelve cembranoids, deheiculatins A-L, were isolated from the leaves and twigs of Macaranga deheiculata . Their structures were elucidated on the basis of spectroscopic data. Five of these compounds displayed moderate inhibitory activity against human and/or mouse 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). 20-Oxygenated cembranes are rare. Graphical abstract: Cembranoids, deheiculatins A-L, were isolated from the leaves and twigs of Macaranga deheiculata . Dehiculatins C and G-J exhibited 11β-HSD1 inhibitory activity. Highlights: Twelve cembranoids were isolated from Macaranga deheiculata. Deheiculatins C and G-L displayed moderate inhibitory activity against human and/or mouse11β-HSD1. 20-oxygenated cembranes are rare.