Alliacane sesquiterpenoids from submerged cultures of the basidiomycete Inonotus sp. BCC 22670. (April 2017)

• Record Type: Journal Article
• Authors: Isaka, Masahiko; Sappan, Malipan; Supothina, Sumalee; Srichomthong, Kitlada; Komwijit, Somjit; Boonpratuang, Thitiya
• Is Part Of: Phytochemistry. Volume 136(2017)
• Page Start: 175
• Page End: 181
• Publication Date: 2017-04
• Subjects: Inonotus -- Hymenochaetaceae -- Alliacane -- Antibacterial activity -- Antiviral activity; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2017.01.018
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: Nine alliacane sesquiterpenoids, inonoalliacanes A–I, were isolated from culture broth of the basidiomycete Inonotus sp. BCC 22670. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data. The absolute configuration of inonoalliacane F was determined by application of the modified Mosher's method. Inonoalliacane A, the most abundant sesquiterpene constituent, exhibited moderate antibacterial activity against Bacillus cereus, whereas inonoalliacane B showed antiviral activity against herpes simplex virus type 1. Graphical abstract: Nine alliacane sesquiterpenoids, inonoalliacanes A–I, were isolated from cultures of Inonotus sp. BCC 22670. Highlights: Nine alliacane sesquiterpenes were isolated from cultures of Inonotus sp. BCC 23706. These structures were elucidated on the basis of spectral data. The absolute configuration of inonoalliacane F was determined by Mosher's method. Antibacterial and antiviral activities of the isolated compounds were evaluated.