Fabrication of antibacterial electrospun nanofibers with vancomycin-carbon nanotube via ultrasonication assistance. (15th April 2017)

• Record Type: Journal Article
• Authors: Liu, Chunmei; Shi, Hengchong; Yang, Huawei; Yan, Shunjie; Luan, Shifang; Li, Yuchao; Teng, Mouyong; Khan, Ather Farooq; Yin, Jinghua
• Is Part Of: Materials & design. Volume 120(2017)
• Page Start: 128
• Page End: 134
• Publication Date: 2017-04-15
• Subjects: TPU electrospun nanofibers -- Carbon nanotube -- Vancomycin -- Ultrasonication assistance -- Antibacterial property; Materials -- Periodicals; Engineering design -- Periodicals; Matériaux -- Périodiques; Conception technique -- Périodiques; Electronic journals; 620.11
• DOI: 10.1016/j.matdes.2017.02.008
• Languages: English
• ISSNs: 0264-1275

Abstract

Abstract: The aggregation of multi-walled carbon nanotubes (MWCNT) into the polymer matrix and weak bactericidal property of MWCNT usually limit the application of MWCNT in the infection resistance. To solve the above problem, vancomycin hydrochloride modified multi-walled carbon nanotube (Van-MWCNT) via the chemical reaction of the MWCNT's inherent carboxyl group and the Van's amide group was well designed and synthesized. Then, Van-MWCNT was in-situ anchored onto thermoplastic polyurethane (TPU) electrospun nanofibers (TPU/Van-MWCNT) by ultrasonication assistance to achieve the bactericidal property. The above preparation process was facile, non-toxic with the green solvent-water as medium. At the same time, it also effectively reduced the aggregation of Van-MWCNT into the electrospun nanofibers. The minimal inhibitory concentration (MIC) of Van-MWCNT against S. aureus was obviously lower than that of MWCNT. And the TPU/Van-MWCNT exhibited excellent antibacterial properties evaluated through the spread plate test and field emission scanning electron microscope (FESEM). The as-prepared antibacterial TPU electrospun nanofibers have potential application in wound dressing. Graphical abstract: Highlights: Vancomycin hydrochloride modified multi-walled carbon nanotube was well designed and synthesized as antibacterial agent Van-MWCNT was anchored onto TPU electrospun nanofibers by ultrasonication assistance to achieve bactericidal property TPU/Van-MWCNT exhibit excellent antibacterial properties and have potential application in wound dressing