Dietary fibre and phenolic-rich extracts from Musa paradisiaca inflorescence ameliorates type 2 diabetes and associated cardiovascular risks. (April 2017)

• Record Type: Journal Article
• Authors: Arun, K.B.; Thomas, Sithara; Reshmitha, T.R.; Akhil, G.C.; Nisha, P.
• Is Part Of: Journal of functional foods. Volume 31(2017)
• Page Start: 198
• Page End: 207
• Publication Date: 2017-04
• Subjects: Plantain inflorescence -- Dietary fibre -- Phenolics -- ROS scavenging -- Glucose uptake -- ACE inhibition; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2017.02.001
• Languages: English
• ISSNs: 1756-4646

Abstract

Highlights: Musa paradisiaca ( Nendran ) inflorescence (PI) rich in dietary fibre and phenolics. Soluble dietary fibre from PI exhibits glucose and cholesterol absorption capacity. PI methanol extract (PIM) inhibit ROS production in L6 myoblast cells. PIM inhibits α–amylase, α–glucosidase antiglycation; enhances glucose uptake in L6. PIM inhibits LDL oxidation and ACE activity. Abstract: The present study investigated nutraceutical properties of Musa paradisiaca (Nendran variety) inflorescence (PI). PI was found to be a rich source of soluble (SDF) and insoluble dietary fibre (12.45 and 53.31% respectively). SDF exhibited potential glucose and cholesterol adsorption capacity. Ethyl acetate (PIE) and methanol (PIM) extracts of PI were analyzed for phenolics content, antioxidant activities, antidiabetic and cardiovascular protection efficacy. PIM exhibited significant ABTS free radical scavenging activity (IC50 -57.2 ± 1.15 μg/mL) and inhibited the production of reactive oxygen species in L6 myoblasts in a dose-dependent manner. PIM also demonstrated potential inhibition of carbohydrate digestive enzymes (α-amylase and α-glucosidase), interfered with the production of glycated end products (IC50 -142.27 ± 1.09 μg/mL) and enhanced glucose uptake in L6 myoblasts. PIM inhibited LDL oxidation (IC50 -169.52 ± 1.77 μg/mL) and ACE, indicating its protective role against cardiovascular risk factors. The study demonstrated the nutraceutical potential of PI in ameliorating type 2 diabetes and associated cardiovascular problems.