Rationally designed non-enzymatic fluorogenic 'turn-on' probe for uric acid. (October 2015)

• Record Type: Journal Article
• Authors: Pradhan, Tuhin; Maiti, Sukhendu; Kumar, Rajesh; Lee, Yun Hak; Kim, Jong Wan; Lee, Joung Hae; Kim, Jong Seung
• Is Part Of: Dyes and pigments. Volume 121(2015)
• Page Start: 1
• Page End: 6
• Publication Date: 2015-10
• Subjects: Uric acid -- Fluorescence -- BODIPY -- Non-enzymatic -- PET -- Hydrogen bonding; Dyes and dyeing -- Periodicals; Pigments -- Periodicals; 667.2
• DOI: 10.1016/j.dyepig.2015.05.001
• Languages: English
• ISSNs: 0143-7208

Abstract

Abstract: The simple and cost-effective detection of uric acid in serum or urine is highly desirable as uric acid acts as a biomarker for various diseases. Herein, we report a rationally designed, non-enzymatic probe for the detection of uric acid in serum samples over a wide range of concentrations (lower: ∼60 μM, higher: ∼700 μM and normal: ∼120–380 μM) with 'turn-on' fluorogenic behaviour. Graphical abstract: The simple and cost-effective detection of uric acid in serum or urine is highly desirable as uric acid acts as a biomarker for various diseases. Herein, we report a rationally designed, non-enzymatic probe for the detection of uric acid in serum samples over a wide range of concentrations (lower: ∼60 μM, higher: ∼700 μM and normal: ∼120–380 μM) with 'turn-on' fluorogenic behaviour. Highlights: First report of non-enzymatic 'turn-on' fluorogenic detection of uric acid (UA). A non-invasive method that discriminate UA from other analytes in serum sample. Probe8 utilizes hydrogen bonding interactions for uric acid detection. A wide range of concentrations was detected with probe8 .