Diastereoselective tandem oxidation/Michael/aldol reaction: unprecedented formation of dispirocyclopentanebisoxindoles and dispiro[acenaphthylene-1, 1′-cyclopentane-3′, 1′′-acenaphthylene]-2, 2′′diones. Issue 9 (8th February 2017) - Suman, Koorathota
Abstract : Single-step construction of a dispirocyclopentane ring with four chiral centers via the formation of two new C–C bonds. Abstract : An unprecedented tandem oxidation/Michael/aldol reaction is reported. The diastereoselective formation of only a single isomer of dispirocyclopentanebisoxindole and dispiro[acenaphthylene-1, 1′-cyclopentane-3′, 1′′-acenaphthylene]-2, 2′′dione is presented. The reaction generates two new C–C bonds and two all-carbon quaternary chiral stereocenters in a single step.