AIEgen-functionalised mesoporous silica nanoparticles as a FRET donor for monitoring drug delivery. Issue 3 (18th January 2017)

• Record Type: Journal Article
• Authors: Wang, Duo; Chen, Jie; Ren, Li; Li, Qinglan; Li, Dongdong; Yu, Jihong
• Is Part Of: Inorganic chemistry frontiers. Volume 4:Issue 3(2017)
• Page Start: 468
• Page End: 472
• Publication Date: 2017-01-18
• Subjects: Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/c6qi00488a
• Languages: English
• ISSNs: 2052-1553

Abstract

Abstract : AIEgen-functionalised mesoporous silica nanoparticles can be used for cell imaging and monitoring the drug release process by different emission colours based on the FRET mechanism. Abstract : Aggregation-induced emission luminogens (AIEgens), tetraphenylethene, were post grafted onto mesoporous silica nanoparticles to form AIEgen-functionalised mesoporous materials. The obtained blue-emitting materials can serve as a fluorescence resonance energy transfer (FRET) donor for monitoring the release process of doxorubicin hydrochloride (DOX) as an acceptor by the change of the fluorescent signal, showing potential application in imaging-guided therapy.