A DOTAM‐based paraCEST agent favoring TSAP geometry for enhanced amide proton chemical shift dispersion and temperature sensitivity. (4th February 2013)

• Record Type: Journal Article
• Authors: Stevens, Todd K.; Milne, Mark; Elmehriki, Adam A. H.; Suchý, Mojmír; Bartha, Robert; Hudson, Robert H. E.
• Is Part Of: Contrast media & molecular imaging. Volume 8:Number 3(2013:May/Jun.)
• Page Start: 289
• Page End: 292
• Publication Date: 2013-02-04
• Subjects: PARACEST -- MRI -- temperature -- TSAP -- SAP -- thulium -- t‐butyl amide; Diagnostic imaging -- Periodicals; Magnetic resonance imaging -- Periodicals; Contrast media (Diagnostic imaging) -- Periodicals; Contrast Media -- Periodicals; Diagnostic Imaging -- Periodicals; Substances de contraste -- Périodiques; Diagnostics moléculaires -- Périodiques; Imagerie médicale; Substance de contraste; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.0754
• DOI: 10.1002/cmmi.1527
• Languages: English
• ISSNs: 1555-4309

Abstract

Abstract : The Tm 3+ chelate of DOTAM [1, 4, 7, 10‐tetrakis(carbamoylmethyl)‐1, 4, 7, 10‐tetraazacyclododecane] possessing sterically demanding t‐butyl amide substitution favors TSAP geometry. This chelate displayed a paraCEST signal associated with the highly shifted amide proton signal at approximately −100 ppm that was beyond the frequency of macromolecule magnetization transfer. This signal also displayed high temperature dependence (0.57 ppm °C −1 ) in the range of 35–42 °C and at neutral pH. Copyright © 2013 John Wiley & Sons, Ltd. Abstract : The Tm 3+ chelate of DOTAM [1, 4, 7, 10‐tetrakis(carbamoylmethyl)‐1, 4, 7, 10‐tetraazacyclododecane] possessing sterically demanding t‐butyl amide substitution favors TSAP geometry. This chelate displays a paraCEST signal associated with the amide proton signal at approximately −100 ppm and thus escapes severe interference associated with macromolecule magnetization transfer. This paraCEST signal also displays high temperature dependence (0.57 ppm °C −1 ) in the range of 35–42 °C and at neutral pH.