Percutaneous cryoablation of renal tumours: outcomes from 171 tumours in 147 patients. (12th April 2013)

• Record Type: Journal Article
• Authors: Breen, David J.; Bryant, Timothy J.; Abbas, Ausami; Shepherd, Beth; McGill, Neil; Anderson, Jane A.; Lockyer, Richard C.; Hayes, Matthew C.; George, Steve L.
• Is Part Of: BJU international. Volume 112:Number 6(2013:Sep.)
• Page Start: 758
• Page End: 765
• Publication Date: 2013-04-12
• Subjects: renal tumours -- percutaneous image‐guided ablation -- percutaneous cryoablation; Genitourinary organs -- Diseases -- Periodicals; Genitourinary organs -- Surgery -- Periodicals; Urology -- Periodicals; 616.6
• DOI: 10.1111/bju.12122
• Languages: English
• ISSNs: 1464-4096

Abstract

Abstract : Objective: To evaluate the technical and oncological efficacy of an image‐guided cryoablation programme for renal tumours. Patients and Methods: A prospective analysis of technical and radiological outcomes was undertaken after treatment of 171 consecutive tumours in 147 patients. Oncological efficacy in a subset of 125 tumours in 104 patients with >6 months' radiological follow‐up and a further subset of 62 patients with solitary, biopsy‐proven renal carcinoma was also analysed. Factors influencing technical success, as determined by imaging follow‐up, and complication rates were statistically analysed using a statistics software package and logistic regression analyses. Results: No variables were found to predict subtotal treatment, although gender ( P = 0.08), tumour size of >4 cm ( P = 0.09) and central location of tumour ( P = 0.07) approached significance. Upper pole location was the single variable that was found to predict complications ( P = 0.006). Among the 104 patients (125 tumours), radiologically assessed at ≥6 months and with a mean radiological follow‐up of 20.1 months, we found a single case of unexpected late local recurrence. Conclusion: Percutaneous image‐guided cryoablation, at a mean of 20.1 months' follow‐up, appears to provide a safe and effective treatment option with a low complication rate. Anteriorly sited tumours should not be considered a contraindication for percutaneous image‐guided cryoablation.