Mid‐life environmental enrichment increases synaptic density in CA1 in a mouse model of Aβ‐associated pathology and positively influences synaptic and cognitive health in healthy ageing. Issue 8 (14th March 2017)

• Record Type: Journal Article
• Authors: Stuart, Kimberley E.; King, Anna E.; Fernandez‐Martos, Carmen M.; Dittmann, Justin; Summers, Mathew J.; Vickers, James C.
• Is Part Of: Journal of comparative neurology. Volume 525:Issue 8(2017)
• Page Start: 1797
• Page End: 1810
• Publication Date: 2017-03-14
• Subjects: Alzheimer's disease -- Aβ -- environmental enrichment -- transgenic mouse -- brain‐derived neurotrophic factor -- cognitive function -- RRID:SCR_003070 -- RRID:MGI_3665286 -- RRID:SCR_002668 -- RRID:AB_570874 -- RRID:AB_262185 -- RRID:AB_303248 -- RRID:AB_1860491 -- RRID:AB_2263126 -- RRID:AB_2278725 -- RRID:AB_476743 -- RRID:AB_630940 -- RRID: SCR_002865; Comparative neurobiology -- Periodicals; Neurology -- Periodicals; 616
• DOI: 10.1002/cne.24156
• Languages: English
• ISSNs: 0021-9967

Abstract

Abstract: Early‐life cognitive enrichment may reduce the risk of experiencing cognitive deterioration and dementia in later‐life. However, an intervention to prevent or delay dementia is likely to be taken up in mid to later‐life. Hence, we investigated the effects of environmental enrichment in wildtype mice and in a mouse model of Aβ neuropathology (APPSWE /PS1dE9 ) from 6 months of age. After 6 months of housing in standard laboratory cages, APPSWE /PS1dE9 ( n = 27) and healthy wildtype ( n = 21) mice were randomly assigned to either enriched or standard housing. At 12 months of age, wildtype mice showed altered synaptic protein levels and relatively superior cognitive performance afforded by environmental enrichment. Environmental enrichment was not associated with alterations to Aβ plaque pathology in the neocortex or hippocampus of APPSWE /PS1dE9 mice. However, a significant increase in synaptophysin immunolabeled puncta in the hippocampal subregion, CA1, in APPSWE /PS1dE9 mice was detected, with no significant synaptic density changes observed in CA3, or the Fr2 region of the prefrontal cortex. Moreover, a significant increase in hippocampal BDNF was detected in APPSWE /PS1dE9 mice exposed to EE, however, no changes were detected in neocortex or between Wt animals. These results demonstrate that mid to later‐life cognitive enrichment has the potential to promote synaptic and cognitive health in ageing, and to enhance compensatory capacity for synaptic connectivity in pathological ageing associated with Aβ deposition. Abstract : A transgenic mouse model of Alzheimer's disease exposed to an enriched environment following Aβ deposition, showed an increase in CA1 synaptic density and elevated hippocampal BDNF, despite no changes to Aβ pathological burden. Thus, stimulation from the environment in mid‐life may enhance the capacity for synaptic connectivity in pathological ageing.