Virus‐Mimetic Fusogenic Exosomes for Direct Delivery of Integral Membrane Proteins to Target Cell Membranes. Issue 13 (6th February 2017)

• Record Type: Journal Article
• Authors: Yang, Yoosoo; Hong, Yeonsun; Nam, Gi‐Hoon; Chung, Jin Hwa; Koh, Eunee; Kim, In‐San
• Is Part Of: Advanced materials. Volume 29:Issue 13(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-02-06
• Subjects: exosomes -- membrane protein -- nanoplatform -- viral fusogen; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201605604
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : An efficient system for direct delivery of integral membrane proteins is successfully developed using a new biocompatible exosome‐based platform. Fusogenic exosomes harboring viral fusogen, vascular stomatitis virus (VSV)‐G protein, can fuse with and modify plasma membranes in a process called "membrane editing." This can facilitate the transfer of biologically active membrane proteins into the target cell membranes both in vitro and in vivo.