Metal–free Decarboxylative Amination: An Alternative Approach Towards Regioselective Synthesis of β‐Carboline N‐fused Imidazoles. Issue 7 (27th January 2017)

• Record Type: Journal Article
• Authors: Singh, Dharmender; Kumar, Vipin; Devi, Nisha; Malakar, Chandi C.; Shankar, Ravi; Singh, Virender
• Is Part Of: Advanced synthesis & catalysis. Volume 359:Issue 7(2017)
• Page Start: 1213
• Page End: 1226
• Publication Date: 2017-01-27
• Subjects: Decarboxylative amination -- Iodine catalysed -- Oxidative amination -- α-Amino acids -- β-Carboline fused; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201600970
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: Due to significant activity profile and natural abundance of β‐carboline containing alkaloids, β‐carboline N ‐fused imidazole derivatives were designed and iodine assisted efficient approach was formulated for the regioselective synthesis of designed prototypes via decarboxylative amination of natural α‐amino acids with 1‐formyl pyrido[3, 4‐ b ]indoles. Additionally, oxidative amination with benzyl amines was also investigated for the synthesis of these β‐carboline D‐ring containing frameworks. Abstract :