Recent progress in transdermal sonophoresis. (19th May 2017)

• Record Type: Journal Article
• Authors: Ita, Kevin
• Is Part Of: Pharmaceutical development and technology. Volume 22:Number 4(2017)
• Page Start: 458
• Page End: 466
• Publication Date: 2017-05-19
• Subjects: Acoustic streaming -- cavitation -- drug delivery -- sonophoresis -- transdermal; Drug delivery systems -- Periodicals; Pharmaceutical technology -- Periodicals; Drugs -- Administration -- Research -- Periodicals; Drug Delivery Systems -- Periodicals; Pharmaceutical Preparations -- Periodicals; Technology, Pharmaceutical -- Periodicals; 615
• DOI: 10.3109/10837450.2015.1116566
• Languages: English
• ISSNs: 1083-7450

Abstract

Abstract: Transdermal drug administration has a number of advantages that cannot be leveraged for therapeutic benefits because of the robust barrier provided by the stratum corneum. One of the promising techniques for circumventing the stratum corneum is sonophoresis – the use of ultrasound for facilitating transdermal drug delivery. In this review, the mechanisms underlying sonophoresis and the utilization of the technique for transdermal delivery are discussed. The challenges of this mode of drug administration have also been highlighted and insight from a number of toxicological studies is described.