Electroconductive nanoengineered biomimetic hybrid fibers for cardiac tissue engineering. Issue 13 (21st March 2017)

• Record Type: Journal Article
• Authors: Allison, Shelby; Ahumada, Manuel; Andronic, Cristina; McNeill, Brian; Variola, Fabio; Griffith, May; Ruel, Marc; Hamel, Veronique; Liang, Wenbin; Suuronen, Erik J.; Alarcon, Emilio I.
• Is Part Of: Journal of materials chemistry. Volume 5:Issue 13(2017)
• Page Start: 2402
• Page End: 2406
• Publication Date: 2017-03-21
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c7tb00405b
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Collagen–nanosilver fibres stimulated connexin-43 and proliferation of cardiomyocytes under electrical stimulation and prevented biofilm formation and did not activate macrophages. Abstract : We report for the first time the preparation of a fibrous material composed of surface grafted spherical nanosilver and collagen using one-step electrospinning. The resulting composite showed comparable morphology to the control without nanosilver, but had improved electrical conductivity. Under electrical stimulation, fibrous materials containing nanosilver increased connexin-43 expression and proliferation of neonatal cardiomyocytes. Furthermore, composites containing nanosilver prevented biofilm formation but did not activate macrophages.