Copper-catalyzed tandem trifluoromethylation/cyclization of internal alkynes. Issue 11 (11th November 2014)

• Record Type: Journal Article
• Authors: Ji, Yun-Long; Lin, Jin-Hong; Xiao, Ji-Chang; Gu, Yu-Cheng
• Is Part Of: Organic chemistry frontiers. Volume 1:Issue 11(2014)
• Page Start: 1280
• Page End: 1284
• Publication Date: 2014-11-11
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c4qo00240g
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : Copper-catalyzed tandem trifluoromethylation/cyclization of internal alkynes with Umemoto's reagent leading to 3-trifluoromethyl-1, 2-dihydronaphthalene derivatives in moderate to good yields is described. Abstract : Copper-catalyzed tandem trifluoromethylation/cyclization of internal alkynes with Umemoto's reagent leads to 3-trifluoromethyl-1, 2-dihydronaphthalene derivatives in moderate to good yields. The utility of this copper-catalyzed tandem reaction was demonstrated by oxidizing and reducing the trifluoromethylated product to give naphthalene and tetrahydronaphthalene, respectively, and the development of a short route to a trifluoromethylated analogue of Nafoxidine.