Montmorillonite‐K10‐Catalyzed Microwave‐Assisted Direct Amidation of Unactivated Carboxylic Acids with Amines: Maintaining Chiral Integrity of Substrates. Issue 3 (2nd February 2017)

• Record Type: Journal Article
• Authors: Kumar, Manoranjan; Sharma, Sushila; Thakur, Krishana; Nayal, Onkar S.; Bhatt, Vinod; Thakur, Maheshwar S.; Kumar, Neeraj; Singh, Bikram; Sharma, Upendra
• Is Part Of: Asian journal of organic chemistry. Volume 6:Issue 3(2017)
• Page Start: 342
• Page End: 346
• Publication Date: 2017-02-02
• Subjects: amidation -- amines -- carboxylic acids -- microwave chemistry -- montmorillonite K10; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.201600590
• Languages: English
• ISSNs: 2193-5807

Abstract

Abstract: A green, microwave‐assisted methodology for the selective direct amidation of carboxylic acids with amines, using montmorillonite K10 as a heterogeneous catalyst, has been developed. This is an efficient transition‐metal‐free, montmorillonite‐K10‐catalyzed direct amidation of carboxylic acids. The method is compatible with sterically hindered α‐branched, aliphatic, benzylic, aromatic, unsaturated and conjugated carboxylic acids. Moreover, chiral integrity of substrates remained unchanged after the reaction. Abstract : A green, microwave‐assisted methodology for the selective direct amidation of carboxylic acids with amines, using montmorillonite K10 as a heterogeneous catalyst, has been developed. This is an efficient transition‐metal‐free, montmorillonite‐K10‐catalyzed direct amidation of carboxylic acids. The method is compatible with several carboxylic acids bearing different functionalities. Moreover, chiral integrity of substrates remained unchanged after the reaction.