Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition. Issue 2 (19th December 2016)

• Record Type: Journal Article
• Authors: Won, Sangho; Richards, Sarah-Jane; Walker, Marc; Gibson, Matthew I.
• Is Part Of: Nanoscale horizons. Volume 2:Issue 2(2017)
• Page Start: 106
• Page End: 109
• Publication Date: 2016-12-19
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c6nh00202a
• Languages: English
• ISSNs: 2055-6756

Abstract

Abstract : Response polymer gates are employed to enable external control of glycan expression on the surface of multivalent nanoparticles. Abstract : Nature dynamically controls carbohydrate expression on cells rather than static presentation. Here we report synthetic glycosylated nanoparticles that contain polymeric 'gates' to enable external control ( via temperature changes) of glycan surface expression, as an alternative to enzymatic control in nature. This approach offers a new dynamic multivalent scaffold for glycan recognition.