A general [18F]AlF radiochemistry procedure on two automated synthesis platforms. Issue 1 (25th January 2017)

• Record Type: Journal Article
• Authors: Allott, L.; Da Pieve, C.; Turton, D. R.; Smith, G.
• Is Part Of: Reaction chemistry & engineering. Volume 2:Issue 1(2017)
• Page Start: 68
• Page End: 74
• Publication Date: 2017-01-25
• Subjects: Reaction mechanisms (Chemistry) -- Periodicals; Chemical engineering -- Periodicals; Chemical engineering; Reaction mechanisms (Chemistry); Periodicals; 547.705
• DOI: 10.1039/c6re00204h
• Languages: English
• ISSNs: 2058-9883

Abstract

Abstract : The first general [ 18 F]AIF automated radiolabelling procedure developed on the GE Tracerlab FX FN (Left) and Trasis AllInOne (Right) platforms. Abstract : The aluminium fluoride-18 ([ 18 F]AlF) radiolabelling procedure has generated great interest because it is a simple, one-pot method that can be used to directly radiolabel small molecules, peptides and proteins without the requirement for a [ 18 F]fluoride drying step. Reported here is the development of an automated [ 18 F]AlF radiolabelling procedure of three different precursors (one small molecule and two peptides) on two automated synthesis platforms: GE TRACERlab FXFN and Trasis AllInOne (AIO). Aiming at the clinical translatability of a [ 18 F]AlF radiosynthetic methodology, the use of both platforms yielded radioconjugates with >98% radiochemical purity (RCP) within 26–35 min and required a single rapid purification step. The Trasis AIO platform gave improved [ 18 F]fluoride incorporation, and generally produced radioconjugates with a higher radiochemical yield (RCY) and effective specific activities (SA) when compared to the GE TRACERlab FXFN system.