A scalable and safe continuous flow procedure for in-line generation of diazomethane and its precursor MNU. Issue 6 (21st December 2016)

• Record Type: Journal Article
• Authors: Lehmann, H.
• Is Part Of: Green chemistry. Volume 19:Issue 6(2017)
• Page Start: 1449
• Page End: 1453
• Publication Date: 2016-12-21
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/c6gc03066a
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : A green approach towards the on-demand in-line generation of MNU and diazomethane in a continuous flow. Abstract : Diazomethane is a valuable C1 -building block for organic synthesis. Due to its intrinsic reactivity and instability, handling of this reagent is associated with serious safety hazards. Herein we present a simple and robust continuous flow process, allowing a safe and on-demand generation of diazomethane with a productivity of 95–117 mmol h −1 . The developed two-step process starts from non-hazardous N -methylurea, and generates and consumes N -methyl- N -nitrosourea (MNU) and diazomethane, thus enabling a safe and convenient scale-up to a multi-gram scale in a conventional synthesis laboratory.