A spatially distributed computational model of brain cellular metabolism. (7th July 2015)

• Record Type: Journal Article
• Authors: Calvetti, Daniela; Cheng, Yougan; Somersalo, Erkki
• Is Part Of: Journal of theoretical biology. Volume 376(2015)
• Page Start: 48
• Page End: 65
• Publication Date: 2015-07-07
• Subjects: Reaction–diffusion equation -- Multi-domain model -- Reduction of dimensionality -- Well-mixed lumped model -- Krogh cylinder; Biology -- Periodicals; Biological Science Disciplines -- Periodicals; Biology -- Periodicals; Biologie -- Périodiques; Theoretische biologie; Biology; Periodicals; 571.05
• DOI: 10.1016/j.jtbi.2015.03.037
• Languages: English
• ISSNs: 0022-5193

Abstract

Abstract: This paper develops a three-dimensional spatially distributed model of brain cellular metabolism and investigates how the locus of the synaptic activity in reference to the capillaries and diffusion affects the behavior of the model, a type of analysis which is impossible to carry out in spatially lumped models, which are shown to be consistent spatially averaged approximations of the distributed model. To avoid a geometrically detailed modeling of the complex structure of the tissue consisting of different cell types and the extracellular space, the distributed model is based on a novel multi-domain formulation of reaction–diffusion equations, accounting also for separate mitochondria. The model reduction relating the spatially distributed model and lower dimensional reduced models, including the well-mixed spatially lumped compartment model, is carefully explained. We illustrate the effects of losing the spatial resolution with a computed example which is based on a reduced one-dimensional distributed radial model, and look into how the model behaves when the locus of the synaptic activity in reference to the capillaries is changed. By averaging the fluxes and concentrations in the distributed radial model to correspond to quantities in a lumped model, and further by estimating the parameters in the lumped, we conclude that varying the locus of the synaptic activity in reference to the capillaries alters significantly the lumped model parameters. This observation seems to be consequential for parameter estimation procedures from data when the spatial resolution is insufficient to determine the locus of the activity, indicating that the model uncertainty is an inherent feature of lumped models. Abstract : Highlights: A new spatially distributed model for brain energy metabolism is developed. A standard lumped model is recovered by spatial averaging. The sensitivity of parameter estimation to scale change is demonstrated by computed examples. The question of glucose vs. lactate as metabolites is revisited.