Domino carbometalation/coupling reactions of N-arylpropiolamides: a novel and promising synthetic strategy toward stereocontrolled preparation of highly substituted 3-methyleneindolinones. Issue 31 (29th March 2017)

• Record Type: Journal Article
• Authors: Vessally, E.; Hosseinzadeh-Khanmiri, R.; Ghorbani-Kalhor, E.; Es'haghi, M.; Bekhradnia, A.
• Is Part Of: RSC advances. Volume 7:Issue 31(2017)
• Page Start: 19061
• Page End: 19072
• Publication Date: 2017-03-29
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c7ra01371j
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : 3-Methyleneindolinone derivatives are important structural motifs found in many compounds of natural occurrence and pharmacological significance. Abstract : 3-Methyleneindolinone derivatives are important structural motifs found in many compounds of natural occurrence and pharmacological significance. However, despite their wide importance, mild and highly efficient stereoselective synthesis of ( E )- and ( Z )-3-methyleneindolinones still remains to be a difficult problem. Therefore, the development of new synthetic methods for their stereocontrolled preparation is of prime importance in organic synthesis. In this mini review, we highlight the advances in stereoselective synthesis of mono- and disubstituted-3-methyleneindolinones through metal-catalyzed intramolecular cyclization of N -arylpropiolamides from 1988 to 2017.