Development of an enantioselective amine–silver co-catalyzed Conia-ene reaction. Issue 28 (22nd March 2017)

• Record Type: Journal Article
• Authors: Blümel, M.; Hack, D.; Ronkartz, L.; Vermeeren, C.; Enders, D.
• Is Part Of: Chemical communications. Volume 53:Issue 28(2017)
• Page Start: 3956
• Page End: 3959
• Publication Date: 2017-03-22
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c7cc01807j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : The development of a novel cooperative catalytic system for an amine–silver co-catalyzed Conia-ene reaction of alkyne-tethered C–H-acidic compounds is reported. Abstract : The development of a novel cooperative catalytic system for an amine–silver co-catalyzed Conia-ene reaction of alkyne-tethered C–H-acidic compounds is reported. By using a cost-effective silver salt and a small diamine for the 5- exo-dig -cyclization the cyclopentane products are obtained in very good yields. The enantioselectivity of the reaction could be controlled by exchanging the diamine co-catalyst with a cinchona-derived primary amine.