Diabetes mellitus and decompensated cirrhosis: Risk of hepatic encephalopathy in different age groups (糖尿病与失代偿性肝硬化：不同年龄组的肝性脑病风险). (8th July 2013)

• Record Type: Journal Article
• Authors: Butt, Zeeshan; Jadoon, Nauman A.; Salaria, Osman N.; Mushtaq, Kamran; Riaz, Irbaz B.; Shahzad, Ahmed; Hashmi, Ali M.; Sarwar, Shahid
• Is Part Of: Journal of diabetes. Volume 5:Number 4(2013:Oct.)
• Page Start: 449
• Page End: 455
• Publication Date: 2013-07-08
• Subjects: diabetes complications -- hepatic encephalopathy -- liver cirrhosis -- old age; 糖尿病并发症，肝性脑病，肝硬化，老龄; Diabetes -- Periodicals; 618.3646005
• DOI: 10.1111/1753-0407.12067
• Languages: English
• ISSNs: 1753-0393

Abstract

Abstract: Background: The aim of the present study was to examine the association of diabetes mellitus (DM) with the prevalence and severity of hepatic encephalopathy (HE) in patients with decompensated cirrhosis (DC) and determine the impact of age and gender on this relationship. Methods: West Haven criteria was used to prospectively evaluate 352 consecutive patients with DC for the presence of HE. Detailed clinicobiochemical profiling of patients was performed. Categorical data and ordered categorical variables were evaluated using the Chi‐squared test for independence and trend, respectively. Continuous normal and non‐parametric data were evaluated using the t‐test and Mann–Whitney U‐test, respectively. Results: At the time of admission, HE was present in 50.3% of patients. In all, 118 patients had DM (33.5%). Patients with DM had a significantly higher prevalence (58.5% vs 42.6%; P = 0.03) and severity of HE ( P trend = 0.01) than patients without DM. However, there were no significant differences between the two groups in terms of Child‐Pugh class, MELD scores, the presence of ascites and esophageal varices. Patients with DM had higher platelet counts than those without DM ( P trend = 0.003). In age and gender subgroup analyses, older patients and men with DM had significantly greater evidence of HE ( P = 0.02 and 0.03, respectively). Multivariate analysis showed that DM ( P = 0.03) and older age ( P = 0.006) were independently related to HE, whereas the association of gender was non‐significant. Conclusion: Both DM and older age are independently associated with HE in patients with cirrhosis.