Highly efficient one-pot tandem Friedlander annulation and chemo-selective Csp3–H functionalization under calcium catalysis. Issue 31 (28th March 2017)

• Record Type: Journal Article
• Authors: Singh, Garima; Yaragorla, Srinivasarao
• Is Part Of: RSC advances. Volume 7:Issue 31(2017)
• Page Start: 18874
• Page End: 18882
• Publication Date: 2017-03-28
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra28642a
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Highly efficient and regioselective Friedlander synthesis of 2-methyl-3-acyl quinolines and their chemoselective Csp 3 –H functionalization is described for the first time using Ca(OTf)2 as the sustainable catalyst under solvent free conditions with atom and step economy. Abstract : A highly efficient and regioselective Friedlander synthesis of 2-methyl-3-acyl quinolines is described, which occurs under solvent-free conditions and employs calcium triflate as a sustainable catalyst. For the first time in the literature, these 2-methyl-3-acyl quinolines undergo an in situ chemoselective Csp 3 –H functionalization to furnish structurally enriched quinoline heterocycles in high yields and with atom and step economy.