Is liver transplantation safe and effective in elderly (≥70 years) recipients? A case‐controlled analysis. Issue 12 (6th August 2014)

• Record Type: Journal Article
• Authors: Wilson, Gregory C.; Quillin, R. Cutler; Wima, Koffi; Sutton, Jeffrey M.; Hoehn, Richard S.; Hanseman, Dennis J.; Paquette, Ian M.; Paterno, Flavio; Woodle, E. Steve; Abbott, Daniel E.; Shah, Shimul A.
• Is Part Of: HPB. Volume 16:Issue 12(2014:Dec.)
• Page Start: 1088
• Page End: 1094
• Publication Date: 2014-08-06
• Subjects: Liver -- Diseases -- Periodicals; Biliary tract -- Diseases -- Periodicals; Pancreas -- Diseases -- Periodicals; 616.362005
• DOI: 10.1111/hpb.12312
• Languages: English
• ISSNs: 1365-182X

Abstract

Abstract: Background: Elderly patients are evaluated for liver transplantation (LT) with increasing frequency, but outcomes in this group have not been well defined. Methods: A linkage of the Scientific Registry of Transplant Recipients (SRTR) and the University HealthSystem Consortium (UHC) databases identified 12 445 patients who underwent LT during 2007–2011. Two cohorts were created consisting of, respectively, elderly recipients aged ≥70 years ( n = 323) and recipients aged 18–69 years ( n = 12 122). A 1:1 case‐matched analysis was performed based on propensity scores. Results: Elderly recipients had lower Model for End‐stage Liver Disease (MELD) scores at LT (median 15 versus 19; P < 0.0001), more often underwent transplantation at high‐volume centres (46% versus 33%; P < 0.0001) and more often received grafts from donors aged >60 years (24% versus 15%; P < 0.0001). The two cohorts had similar hospital lengths of stay, in‐hospital mortality, hospital costs and 30‐day readmission rates. There were no differences in graft survival between the two cohorts ( P = 0.10), but elderly recipients had worse longterm overall survival ( P = 0.009). However, a case‐controlled analysis confirmed similar perioperative hospital outcomes, graft survival and longterm patient survival in the two matched cohorts. Conclusions: Elderly LT recipients accounted for <3% of all LTs performed during 2007–2011. Selected elderly recipients have perioperative outcomes and survival similar to those in younger adults.