Concomitant contact allergies to formaldehyde, methylchloroisothiazolinone/methylisothiazolinone, methylisothiazolinone, and fragrance mixes I and II. (November 2016)

• Record Type: Journal Article
• Authors: Pontén, Ann; Bruze, Magnus; Engfeldt, Malin; Hauksson, Inese; Isaksson, Marléne
• Is Part Of: Contact dermatitis. Volume 75:Number 5(2016)
• Page Start: 285
• Page End: 289
• Publication Date: 2016-11
• Subjects: contact allergy -- fragrances -- preservatives -- sex; Contact dermatitis -- Periodicals; 616.51
• DOI: 10.1111/cod.12598
• Languages: English
• ISSNs: 0105-1873

Abstract

Summary: Background: Contact allergies to the preservatives formaldehyde and methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI) have been reported to appear together at a statistically significant level. Recently, revisions concerning the patch test preparations of MCI/MI, MI and formaldehyde have been recommended for the European baseline series. Aim: To investigate (i) the number of concomitant contact allergies to the preservatives, (ii) the number of concomitant contact allergies to the preservatives and the fragrance mixes (FM I and FM II) and (iii) gender differences. Methods: Patients tested with the Swedish baseline series during the period 2012–2014 at the Department of Occupational and Environmental Dermatology in Malmö, Sweden were investigated. Results: 2165 patients were patch tested with the baseline series (34% males and 66% females). Contact allergies to formaldehyde and MCI/MI and/or MI were significantly associated ( p < 0.001). The associations between contact allergy to MCI/MI and/or MI and FM I and/or FM II, and between formaldehyde and FM I and/or FM II as well as, were statistically significant ( p < 0.001). Conclusion: Contact allergies to formaldehyde and MCI/MI and/or MI are significantly associated, as well as contact allergies to these preservatives and fragrance allergy. Males and females do not differ significantly concerning contact allergy to fragrances.