4-Thiazolidinone derivatives: synthesis, antimicrobial, anticancer evaluation and QSAR studies. Issue 111 (16th November 2016)

• Record Type: Journal Article
• Authors: Deep, Aakash; Narasimhan, Balasubrmanian; Lim, Siong Meng; Ramasamy, Kalavathy; Mishra, Rakesh Kumar; Mani, Vasudevan
• Is Part Of: RSC advances. Volume 6:Issue 111(2016)
• Page Start: 109485
• Page End: 109494
• Publication Date: 2016-11-16
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra23006g
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A series of novel 4-thiazolidinone derivatives (1–18 ) was synthesized evaluated for its antimicrobial and anticancer potential. Abstract : A series of 4-thiazolidinone derivatives (1–18 ) was synthesized and tested in vitro for its antimicrobial and anticancer potential. Synthesized compounds were found to be5 more potent antimicrobial agents than anticancer agents. Anticancer screening results indicated that compound 13 (IC50 = 15.18 μM) was the most active anticancer agent and was more potent than the standard drug, carboplatin (IC50 > 100 μM). Antimicrobial activity results indicated that 14 was the most active antimicrobial agent (pMICec = 2.14 μM) and may serve as an important lead for the discovery of novel antimicrobial agents. The QSAR studies indicated that the antibacterial and antifungal activities of the synthesized derivatives against different microbial strains were governed by lipophilic parameter, log P, topological parameter, κα3 and electronic parameters cos E and Nu. E.