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3, 3-Dibromo-2-trifluoromethyl acrylic acid ethyl ester: a versatile platform for the stereoselective preparation of functionalized-α-trifluoromethyl α, β-unsaturated lactones and trifluoromethyl pyrazolinones 1. Issue 12 (27th September 2016)
Record Type:
Journal Article
Title:
3, 3-Dibromo-2-trifluoromethyl acrylic acid ethyl ester: a versatile platform for the stereoselective preparation of functionalized-α-trifluoromethyl α, β-unsaturated lactones and trifluoromethyl pyrazolinones 1. Issue 12 (27th September 2016)
Main Title:
3, 3-Dibromo-2-trifluoromethyl acrylic acid ethyl ester: a versatile platform for the stereoselective preparation of functionalized-α-trifluoromethyl α, β-unsaturated lactones and trifluoromethyl pyrazolinones 1
Abstract : Synthetic routes to multi-functionalized-α-trifluoromethyl α, β-unsaturated lactones and trifluoromethyl pyrazolinones. Abstract : We herein describe a method for synthetic routes to multi-functionalized-α-trifluoromethyl α, β-unsaturated lactones and trifluoromethyl pyrazolinones. This involves a tandem stereoselective functionalization of 3, 3-dibromo-2-trifluoromethyl acrylic acid ethyl ester and intramolecular cyclization reaction to afford precursors for a Suzuki–Miyaura cross-coupling reaction with arylboronic acids.