Β-Carboline-directed decarboxylative acylation of ortho-C(sp2)–H of the aryl ring of aryl(β-carbolin-1-yl)methanones with α-ketoacids under palladium catalysis12. Issue 56 (24th May 2016)

• Record Type: Journal Article
• Authors: Kolle, Shivalinga; Batra, Sanjay
• Is Part Of: RSC advances. Volume 6:Issue 56(2016)
• Page Start: 50658
• Page End: 50665
• Publication Date: 2016-05-24
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra11811a
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A Pd-catalysed β-carboline assisted decarboxylative acylation of ortho -C(sp 2 )–H of aryl ring of aryl(β-carbolin-1-yl)methanones using α-oxocarboxylic acid as the acyl ion source to form (2-aroylaryl)(β-carbolin-2-yl)methanones is demonstrated. Abstract : A palladium-catalysed β-carboline directed decarboxylative acylation of ortho -C(sp 2 )–H of the aryl ring of aryl(β-carbolin-1-yl)methanones using α-oxocarboxylic acid as the acyl ion equivalent to form (2-aroylaryl)(β-carbolin-2-yl)methanones is described. The utility of these products for preparing β-carboline-tethered phthalazine systems is also demonstrated.