Restoring the Processivity of Kinesin Nanomotors. Issue 3 (2nd February 2017)

• Record Type: Journal Article
• Authors: Bhattacharyya, Sanjib; Kim, Kyongwan; Teizer, Winfried
• Is Part Of: Advanced biosystems. Volume 1 :Issue 3 (2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-02-02
• Subjects: EGCG -- gold nanoparticle -- molecular traffic jam -- nanoparticle transport -- restoring biomotor movement; Biological systems -- Periodicals; Biotechnology -- Periodicals; Bioengineering -- Periodicals; Biomedical engineering -- Periodicals; Biological Science Disciplines; Periodicals; Periodicals; 660.6
• DOI: 10.1002/adbi.201600034
• Languages: English
• ISSNs: 2366-7478

Abstract

Abstract : The stepping process of kinesin motors on microtubule networks is instrumental for neuronal communication. Transport deficits, e.g., by intrinsically misfolded tau protein may lead to a range of complications inside the cell, resulting in neurodegenerative dementia processes. It is shown that the addition of gold nanoparticles and epigallocatechin gallate can restore the impaired motor stepping on microtubules.