Synergistic effects of hyperosmotic polymannitol based non-viral vectors and nanotopographical cues for enhanced gene delivery. Issue 112 (22nd November 2016)

• Record Type: Journal Article
• Authors: Garg, PanKaj; Pandey, Shambhavi; Kim, Hong-Nam; Seonwoo, Hoon; Park, Sunho; Choi, Kyoung Soon; Jang, Kyoung-Je; Hyun, Hoon; Choung, Phil-Hoon; Kim, Jangho; Chung, Jong Hoon
• Is Part Of: RSC advances. Volume 6:Issue 112(2016)
• Page Start: 111233
• Page End: 111238
• Publication Date: 2016-11-22
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra09348e
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Here, we report the synergistic effects of hyperosmotic and nanotopographical cues designed using non-viral vectors and nanopatterned matrices for gene delivery. Abstract : Here, we report the synergistic effects of hyperosmotic and nanotopographical cues designed using non-viral vectors and nanopatterned matrices for gene delivery. We show that efficiency of gene delivery can be further enhanced by two factors in combination, indicating the importance of synergistic cues in designing non-viral gene delivery platforms and strategies for gene therapy.