Biocatalytic atom transfer radical polymerization in a protein cage nanoreactor. Issue 14 (21st March 2017)

• Record Type: Journal Article
• Authors: Renggli, Kasper; Sauter, Nora; Rother, Martin; Nussbaumer, Martin G.; Urbani, Raphael; Pfohl, Thomas; Bruns, Nico
• Is Part Of: Polymer chemistry. Volume 8:Issue 14(2017)
• Page Start: 2133
• Page End: 2136
• Publication Date: 2017-03-21
• Subjects: Polymers -- Periodicals; Macromolecules -- Periodicals; Polymerization -- Periodicals; 547.705
• DOI: 10.1039/c6py02155g
• Languages: English
• ISSNs: 1759-9954

Abstract

Abstract : The ATRP-catalyzing enzyme horseradish peroxidase was encapsulated into the protein cage thermosome resulting in an all-protein nanoreactor system for controlled radical polymerizations. Abstract : Incorporation of the ATRP-catalyzing enzyme horseradish peroxidase (HRP) into the cavities of the group II chaperonin thermosome is demonstrated. The resulting nanoreactor was used to polymerize an acrylate under ARGET ATRP conditions. The confined space within the protein cage results in poly(ethylene glycol) methyl ether acrylate (PEGA) with lower molecular weights (poly(styrene)-apparent M n = 4400 g mol −1 ) as well as narrower molecular weight distributions ( Đ = 1.08) compared to polymerizations with the free ATRPase ( M n = 43 700 g mol −1 and a Đ of 1.23).