Gadolinium/DOTA functionalized poly(ethylene glycol)-block-poly(acrylamide-co-acrylonitrile) micelles with synergistically enhanced cellular uptake for cancer theranostics. Issue 56 (24th May 2016)

• Record Type: Journal Article
• Authors: Tong, Guoquan; Fang, Zhuangnian; Huang, Gang; Jing, Yihan; Dai, Shulin; Jiang, Qing; Zhang, Chao; Feng, Shi-Ting; Li, Zi-Ping
• Is Part Of: RSC advances. Volume 6:Issue 56(2016)
• Page Start: 50534
• Page End: 50542
• Publication Date: 2016-05-24
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra04038a
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : The combination of diagnostic and therapeutic functions into a nano-carrier could achieve a delivery system with both accurate diagnosis and delivery capabilities. Abstract : The combination of diagnostic and therapeutic functions into a nano-carrier could achieve a delivery system with both accurate diagnosis and delivery capabilities. Herein, a functionalized polymer of 1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetraacetic acid-poly(ethyleneglycol)- block -poly(acrylamide- co -acrylonitrile) (DOTA-PEG- b -poly(AAm- co -AN)) was designed and synthesized. Doxorubicin (DOX) and gadolinium ions (Gd 3+ ) were loaded into the hydrophobic core and chelated on the shell of the micelles during the self-assembling process to endow the prepared micelles with drug delivery and magnetic resonance imaging functionalities. Such theranostics micelles exhibited noticeable accelerated DOX release with elevated temperature and high proton relaxivity r 1 (25.88 mM −1 s −1 ). Moreover, the Gd 3+ /DOX loaded micelle presented a synergistically enhanced cellular uptake efficiency (2.12 times that of free DOX) as compared with free drug or that loaded in micelles without Gd 3+ . The micelles provide promising application for chemotherapy and simultaneous enhanced magnetic resonance imaging (MRI) of cancer.