A phosphine mediated sequential annulation process of 2-tosylaminochalcones with MBH carbonates to construct functionalized aza-benzobicyclo[4.3.0] derivatives. Issue 28 (23rd March 2017)

• Record Type: Journal Article
• Authors: Zhang, Qinglong; Zhu, Yannan; Jin, Hongxing; Huang, You
• Is Part Of: Chemical communications. Volume 53:Issue 28(2017)
• Page Start: 3974
• Page End: 3977
• Publication Date: 2017-03-23
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc10155k
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A novel phosphine mediated sequential annulation process to construct functionalized aza-benzobicyclo[4.3.0] derivatives has been developed involving a one-pot process. Abstract : A novel phosphine mediated sequential annulation process to construct functionalized aza-benzobicyclo[4.3.0] derivatives has been developed involving a one-pot sequential catalytic and stoichiometric process, which generates a series of benzobicyclo[4.3.0] compounds containing one quaternary center with up to 94% yield and 20 : 1 dr value. In this reaction, MBH carbonates act as 1, 2, 3-C3 synthons.