Enantioselective syntheses of indanes: from organocatalysis to C–H functionalization. (5th January 2016)

• Record Type: Journal Article
• Authors: Borie, Cyril; Ackermann, Lutz; Nechab, Malek
• Is Part Of: Chemical Society reviews. Volume 45:Number 5(2016:Mar.)
• Page Start: 1368
• Page End: 1386
• Publication Date: 2016-01-05
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cs00622h
• Languages: English
• ISSNs: 0306-0012

Abstract

Abstract : The indanyl core is ubiquitous in a large variety of drugs and natural products. Remarkable recent progress has been accomplished in the step-economical assembly of functionalization of chiral indanes by means of enantioselective catalysis, with major progress being achieved in organocatalysis and C–H activation chemistry. Abstract : The indanyl core is ubiquitous in a large variety of drugs and natural products. Importantly, the ever-increasing demand for chiral catalysts bearing this scaffold calls for state of the art methods allowing for a step-economical enantioselective access to this structural motif. We herein summarize the asymmetric syntheses of indanes with a particular focus on asymmetric catalysis, covering the literature of the last decade until July 2015.