Phospho sulfonic acid: an efficient and recyclable solid acid catalyst for the solvent-free synthesis of α-hydroxyphosphonates and their anticancer properties. (17th March 2015)

• Record Type: Journal Article
• Authors: Kalla, Reddi Mohan Naidu; Lee, Hye Ri; Cao, Jiafu; Yoo, Jin-Wook; Kim, Il
• Is Part Of: New journal of chemistry. Volume 39:Number 5(2015:May)
• Page Start: 3916
• Page End: 3922
• Publication Date: 2015-03-17
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c5nj00312a
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : Some of the title compounds synthesized by a green protocol showed potent anticancer activity. Abstract : As a means of developing biologically active compounds, a series of α-hydroxyphosphonates, ArC(OH)PO(OR)2 (Ar = 5-G-2-OHPh; R = Me, Et, iPr, Bu; G = H, Br, Cl, NO2 ), have been synthesized by reacting diversely substituted salicylaldehydes with dialkyl phosphites by employing the Pudovik reaction in the presence of phospho sulfonic acid under neat conditions. The cytotoxicity of the compounds was tested in two human cancer cell lines by using MTT assay. Compounds bearing R = Et; G = Cl, R = Bu; G = Cl, and R = Et; G = NO2 showed good anticancer activity.