Comparison of the Effect of Combination Therapy with an Angiotensin II Receptor Blocker and Either a Low-Dose Diuretic or Calcium Channel Blocker on Cardiac Hypertrophy in Patients with Hypertension. (December 2013)

• Record Type: Journal Article
• Authors: Okura, Takafumi; Miyoshi, Ken-ichi; Irita, Jun; Enomoto, Daijiro; Jotoku, Masanori; Nagao, Tomoaki; Watanabe, Kouki; Matsuoka, Hiroshi; Ashihara, Toshiaki; Higaki, Jitsuo
• Is Part Of: Clinical and experimental hypertension. Volume 35:Number 8(2013)
• Page Start: 563
• Page End: 569
• Publication Date: 2013-12
• Subjects: combination therapy -- angiotensin receptor blocker -- calcium channel blocker -- essential hypertension -- left ventricular hypertrophy; Hypertension -- Chemotherapy -- Periodicals; Hypotensive agents -- Periodicals; 616.132
• DOI: 10.3109/10641963.2013.764892
• Languages: English
• ISSNs: 1064-1963

Abstract

Abstract : Left ventricular hypertrophy (LVH) regression is an important issue in hypertensive patients. Patients with LVH who had received the angiotensin receptor blocker (ARB) treatment for 8 weeks and had not reached the target blood pressure level were enrolled in the study. Patients were assigned to either losartan (50 mg)/hydrochlorothiazide (HCTZ, 12.5 mg) group or ARB + CCB group (usual dose of ARB and calcium channel blocker, CCB). After 48 weeks, LV mass index was found to be reduced significantly in the losartan/HCTZ group but not in the ARB + CCB group. These results suggest that combination therapy of an ARB and diuretic has greater potential to cause regression compared with an ARB and CCB.