Comparison Between Gleason Score and Apparent Diffusion Coefficient Obtained from Diffusion-Weighted Imaging of Prostate Cancer Patients. (1st November 2013)

• Record Type: Journal Article
• Authors: Caivano, Rocchina; Rabasco, Paola; Lotumolo, Antonella; Cirillo, Patrizia; D'Antuono, Felice; Zandolino, Alexis; Villonio, Antonio; Macarini, Luca; Salvatore, Marco; Cammarota, Aldo
• Is Part Of: Cancer investigation. Volume 31:Number 9(2013)
• Page Start: 625
• Page End: 629
• Publication Date: 2013-11-01
• Subjects: Diffusion-weighted imaging -- Magnetic resonance imaging -- Prostate cancer -- ADC -- Gleason score; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.3109/07357907.2013.845673
• Languages: English
• ISSNs: 0735-7907

Abstract

Abstract : Objectives: To correlate the apparent diffusion coefficient (ADC) of prostate cancer patients with pathological Gleason scores (GS). Methods : 40 patients with GS 2 + 3, 3 + 3, 3 + 4, or 4 + 4 were selected. The magnetic resonance imaging (MRI) study was performed adding axial diffusion-weighted imaging (DWI) sequences to the standard MRI protocol. ADC values obtained were correlated with the GS data. Results : Statistically significant differences of ADC ( p < .05) were found among GS groups with a trend of decreasing ADC values with increasing GS. Conclusions : The ADC values may help clinicians to delineate prostate carcinoma, recognizing its high- or low-grade compartments.