In vitro activity of a partially purified and characterized bark extract of Castanea sativa Mill. (ENC®) against Chlamydia spp. (4th March 2017)

• Record Type: Journal Article
• Authors: Papa, Valentina; Ginocchietti, Laura; Budriesi, Roberta; Micucci, Matteo; Costa, Roberta; Biondi, Roberta; Cevenini, Roberto; Chiarini, Alberto; Aldini, Rita; Donati, Manuela; Pollini, Gian Matteo; Cenacchi, Giovanna
• Is Part Of: Ultrastructural pathology. Volume 41:Number 2(2017:Apr.)
• Page Start: 147
• Page End: 153
• Publication Date: 2017-03-04
• Subjects: Antimicrobial activity -- cathelicidin peptide -- chlamydiae -- hydrolysable tannins; Pathology, Cellular -- Periodicals; Ultrastructure (Biology) -- Periodicals; Diagnosis, Electron microscopic -- Periodicals; Microscopy, Electron; Pathology; 616.07582
• DOI: 10.1080/01913123.2016.1275909
• Languages: English
• ISSNs: 0191-3123

Abstract

ABSTRACT: Castanea sativa Mill (ENC®), containing tannins against 33 Chlamydia strains, was compared to SMAP-29 with inhibitory effect against C. trachomatis and C. pneumoniae . The ENC® activity against Chlamydia spp. was evaluated determining the lowest concentration to achieve more than half reduction of intact chlamydial inclusions versus controls. ENC® reduced all Chlamydia strains tested at 1 µg/mL, while SMAP-29 induced reductions of C. trachomatis and C. pneumoniae infectivity at 10 µg/mL. A great reduction of C. trachomatis, C. pneumoniae, and C. abortus infectivity was achieved with a 10 µg/mL ENC® concentration, whereas their infectivity was almost inhibited at 100 µg/mL ENC® concentration.