Regioselective Enzymatic Carboxylation of Bioactive (Poly)phenols. Issue 6 (18th January 2017)

• Record Type: Journal Article
• Authors: Plasch, Katharina; Resch, Verena; Hitce, Julien; Popłoński, Jarosław; Faber, Kurt; Glueck, Silvia M.
• Is Part Of: Advanced synthesis & catalysis. Volume 359:Issue 6(2017)
• Page Start: 959
• Page End: 965
• Publication Date: 2017-01-18
• Subjects: ortho-benzoic acid decarboxylases -- bioactive (poly)phenols -- biocatalysis -- carboxylation -- regioselectivity; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201601046
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: In order to extend the applicability of the regioselective enzymatic carboxylation of phenols, the substrate scope of o ‐benzoic acid (de)carboxylases has been investigated towards complex molecules with an emphasis on flavouring agents and polyphenols possessing antioxidant properties. o ‐Hydroxycarboxylic acid products were obtained with perfect regioselectivity, in moderate to excellent yields. The applicability of this method was proven by the regioselective bio‐carboxylation of resveratrol on a preparative scale with 95% yield. Abstract :