Monodisperse Polypyrrole Nanoparticles Prepared via γ‐Ray Radiolysis of Water: An Efficient Near‐Infrared Photothermal Agent for Cancer Therapy. (20th February 2017)

• Record Type: Journal Article
• Authors: Wang, Jie; Rong, Jielin; Fang, Zhong; Wang, Mozhen; Asif, Anila; Wu, Qichao; Zhou, Xiao; Ge, Xuewu
• Is Part Of: Particle and particle systems characterization. Volume 34:Number 3(2017:Mar.)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-02-20
• Subjects: γ‐ray -- cancer therapy -- near‐infrared light -- polypyrrole nanoparticle -- water radiolysis; Particles -- Periodicals; 620.43
• DOI: 10.1002/ppsc.201600430
• Languages: English
• ISSNs: 0934-0866

Abstract

Abstract : Biosafe nanoparticles with strong near‐infrared (NIR) light photothermal conversion effect can bring effective hyperthermia as one of the promising approaches in cancer therapy. In this work, a new facile and green preparation method of polypyrrole (PPy) nanoparticles based on 60 Co γ‐ray radiation on a simple air‐saturated strong acidic aqueous solution of pyrrole (pH ≤ 1) is studied. According to the MCAP‐FACSIMILE simulation on the concentrations of the radiolysis products of water at the presence of H + and O2, the main strong oxidative radiolysis products· OH and H2 O2 rapidly induce the polymerization of pyrrole. The size of the prepared PPy nanoparticles is about several tens of nanometers and can be controlled by the pH, the concentration of the stabilizer poly(vinyl alcohol), and the absorbed dose rate (the amount of energy absorbed per unit mass of the irradiated material within per unit of time). The PPy nanoparticles show rapid and remarkable NIR (808 nm) photothermal conversion efficiency up to 40.1% in water. Furthermore, the in vitro and in vivo experiments confirm that the prepared PPy nanoparticles exhibit enough strong NIR photothermal effect in tumor cells (4T1 and HeLa) and show a promising prospect as the NIR photothermal agent for the future cancer therapy. Abstract : Polypyrrole (PPy) nanoparticles with uniform size are prepared through a green and convenient strategy of γ‐ray radiation on a simple air‐saturated strong acidic aqueous solution of pyrrole (pH ≤ 1) at room temperature. Both in vitro and in vivo studies indicate that the strong near‐infrared photothermal conversion effect of the PPy nanoparticles can effectively kill cancer cells.