Flow induced conformational transitions of macromolecules and their effect on chromatographic separations. (9th March 2015)

• Record Type: Journal Article
• Authors: Kurganov, Alexander A.; Svec, Frantisek; Kanateva, Anastasiia Yu
• Is Part Of: Polymer. Volume 60(2015)
• Page Start: A1
• Page End: A18
• Publication Date: 2015-03-09
• Subjects: Conformational transitions -- Hydrodynamic chromatography -- Size exclusion chromatography; Polymers -- Periodicals; Polymerization -- Periodicals; Polymères -- Périodiques; Polymérisation -- Périodiques; 547.7
• DOI: 10.1016/j.polymer.2015.01.010
• Languages: English
• ISSNs: 0032-3861

Abstract

Abstract: The conformation of macromolecules is significantly affected, both in free flow as well as when flowing in a confined space. These effects play a major role when passing polymer molecules in solution through a porous system such as chromatographic column or membrane. Current theories take into account the conformational changes of polymer molecules caused by flow, and provide a description of the unusual behavior of macromolecules during chromatographic separation. Due to the changes in conformation, the flow can also cause degradation of polymers which have a very large molar mass. Graphical abstract: