Condensin Regulation of Genome Architecture. Issue 7 (5th January 2017)

• Record Type: Journal Article
• Authors: Rana, Vibhuti; Bosco, Giovanni
• Is Part Of: Journal of cellular physiology. Volume 232:Issue 7(2017:Jul.)
• Page Start: 1617
• Page End: 1625
• Publication Date: 2017-01-05
• Subjects: Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.25702
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract : Condensin complexes exist across all domains of life and are central to the structure and organization of chromatin. As architectural proteins, condensins control chromatin compaction during interphase and mitosis. Condensin activity has been well studied in mitosis but have recently emerged as important regulators of genome organization and gene expression during interphase. Here, we focus our discussion on recent findings on the molecular mechanism and how condensins are used to shape chromosomes during interphase. These findings suggest condensin activity during interphase is required for proper chromosome organization. J. Cell. Physiol. 232: 1617–1625, 2017. © 2016 Wiley Periodicals, Inc. Abstract : This article reviews recent works exploring condensin molecular mechanism and activity. We specifically explore activity during interphase and how condensins are regulated.