Rh/Cu‐Catalyzed Cascade [4+2] Vinylic C−H O‐Annulation and Ring Contraction of α‐Aryl Enones with Alkynes in Air. (9th March 2017)

• Record Type: Journal Article
• Authors: Zhao, Yinsong; Li, Shiqing; Zheng, Xuesong; Tang, Junbin; She, Zhijie; Gao, Ge; You, Jingsong
• Is Part Of: Angewandte Chemie. Volume 129:Number 15(2017)
• Page Start: 4350
• Page End: 4353
• Publication Date: 2017-03-09
• Subjects: Furane -- O-Anellierung -- Pyrylium -- Vinylische C-H-Aktivierung -- α-Arylenon; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201612147
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: An unprecedented Rh‐catalyzed ketone‐directed vinylic C−H activation/[4+2] O ‐annulation of α‐aryl enones with internal alkynes followed by a Cu‐catalyzed ring contraction in air to provide multiaryl‐substituted furan derivatives has been developed. The preliminary mechanism study identifies the active pyrylium salt as the key intermediate.