Cuboid Vesicles Formed by Frame‐Guided Assembly on DNA Origami Scaffolds. (30th December 2016)

• Record Type: Journal Article
• Authors: Dong, Yuanchen; Yang, Yuhe Renee; Zhang, Yiyang; Wang, Dianming; Wei, Xixi; Banerjee, Saswata; Liu, Yan; Yang, Zhongqiang; Yan, Hao; Liu, Dongsheng
• Is Part Of: Angewandte Chemie. Volume 129:Number 6(2017)
• Page Start: 1608
• Page End: 1611
• Publication Date: 2016-12-30
• Subjects: Amphiphile -- DNA-Nanotechnologie -- Gerüstgelenkte Assemblierung -- Selbstorganisation; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201610133
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: We describe the use of a frame‐guided assembly (FGA) strategy to construct cuboid and dumbbell‐shaped hetero‐vesicles on DNA origami nanostructure scaffolds. These are achieved by varying the design of the DNA origami scaffolds that direct the distribution of the leading hydrophobic groups (LHG). By careful selection of LHGs, different types of amphiphiles (both polymer and small‐molecule surfactants) were guided to form hetero‐vesicles, demonstrating the versatility of the FGA strategy and its potential to construct asymmetric and dynamic hetero‐vesicle assemblies with complex DNA nano‐scaffolds.